HYZAAR is in a class of BP medicines
that contain 2 prescription medicines,
an angiotensin receptor blocker (ARB)
and a diuretic (water pill).

HYZAAR is used to:

• lower high blood pressure (hypertension). HYZAAR is not usually the first medicine used to treat high blood pressure (BP).

• lower the chance of stroke in patients with high BP and a heart problem called left ventricular hypertrophy (LVH). HYZAAR may not help black patients with this problem.

HYZAAR is the only combination medicine in its class proven to lower the chance of stroke in patients with high BP and LVH.

The losartan ingredient in HYZAAR can help your blood vessels relax so your blood pressure is lower. The hydrochlorothiazide ingredient in HYZAAR works by making your kidneys pass more water and salt.

HYZAAR has been prescribed by doctors for more than 10 years.

For more than a decade, HYZAAR has proven successful in helping individuals lower their BP. Below is additional information about HYZAAR that you may wish to know:

• HYZAAR is not usually the first medicine used to treat high BP

• HYZAAR helps lower BP in men and women 18 years and older

• HYZAAR helps lower both upper and lower BP numbers

• HYZAAR is a once-daily medicine

Ask your doctor if HYZAAR is right for you.

IMPORTANT SAFETY INFORMATION ABOUT HYZAAR

Do not take HYZAAR if you are pregnant or plan to become pregnant. HYZAAR can harm your unborn baby, causing injury and even death. Stop taking HYZAAR if you become pregnant and call your doctor right away.

Do not take HYZAAR if you are allergic to any ingredients in HYZAAR, are allergic to any sulfonamide-containing ("sulfa") medicines, or are not passing urine. (See the Patient Information about HYZAAR for a complete list of ingredients in HYZAAR.)

Tell your doctor about all of your medical conditions, including if you are pregnant, or planning to become pregnant, are breast-feeding, or plan to breast-feed. HYZAAR can pass into your milk and may harm your baby. You and your doctor should decide if you will take HYZAAR or breast-feed. You should not do both. You also should tell your doctor if you have been vomiting (throwing up), are having diarrhea, are sweating a lot, or are not drinking enough fluids. These could cause you to have low blood pressure. Tell your doctor if you have liver problems, kidney problems, systemic lupus erythematosus (Lupus; SLE), diabetes, asthma, gout, or any allergies.

HYZAAR may cause the following side effects that may be serious:

• Injury or death of unborn babies.

• Allergic reaction. Symptoms of an allergic reaction are swelling of the face, lips, throat, or tongue. Get emergency medical help right away and stop taking HYZAAR.

• Low blood pressure (hypotension). Low blood pressure may cause you to feel faint or dizzy. Lie down if these symptoms occur and call your doctor right away.

• A new or worsening condition called systemic lupus erythematosus (Lupus; SLE).

• If you have kidney problems, you may see a worsening in how well your kidneys work. Call your doctor if you get swelling in your feet, ankles, or hands, or if you have unexplained weight gain.

• If you have liver problems, you may see a worsening in how well your liver works. Call your doctor if you get nausea, pain in the right upper stomach area (abdomen), yellow eyes or skin (which can be itchy).

The most common side effects of HYZAAR in people with high blood pressure are "colds" (upper respiratory infection), dizziness, stuffy nose, back pain, fast or irregular heartbeat (palpitations), and rash.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please read the Patient Information and discuss it with your doctor. The physician Prescribing Information also is available.

This site is intended only for residents of the United States, its territories, and Puerto Rico.

HYZAAR is a registered trademark of E.I. du Pont de Nemours and Company, Wilmington, Delaware, USA.